Cancer Therapy: Preclinical Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells
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چکیده
Purpose: Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction innatural killer (NK) cells has been linked to the development ofmetastases in animalmodels andpatientswith cancer.We investigated the activationofNKcells using influenza vaccine in the perioperative period to eradicate micrometastatic disease. ExperimentalDesign:Both theB16lacZ and4T1 tumormodels in immunocompetentmicewere used to assess the in vivo efficacy of perioperative influenza vaccine administration. In healthy human donors and cancer surgery patients, we assessed NK cell function preand post-influenza vaccination using both in vivo
منابع مشابه
Perioperative influenza vaccination reduces postoperative metastatic disease by reversing surgery-induced dysfunction in natural killer cells.
PURPOSE Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction in natural killer (NK) cells has been linked to the development of metastases in animal models and patients with cancer. We investigated the activation of NK cells using influenza vaccine in the perioperative period to eradicate micrometastatic disease. EXPERIMENTAL DESI...
متن کاملNatural Killer Cells Metastatic Disease by Reversing Surgery-Induced Dysfunction in Perioperative Influenza Vaccination Reduces Postoperative
Purpose: Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction innatural killer (NK) cells has been linked to the development ofmetastases in animalmodels andpatientswith cancer.We investigated the activationofNKcells using influenza vaccine in the perioperative period to eradicate micrometastatic disease. ExperimentalDesign:Both the...
متن کاملRunning Title: Perioperative influenza vaccine enhances NK cell function Perioperative influenza vaccination reduces post-operative metastatic disease by reversing surgery-induced dysfunction in natural killer cells
Running Title: Perioperative influenza vaccine enhances NK cell function Perioperative influenza vaccination reduces post-operative metastatic disease by reversing surgery-induced dysfunction in natural killer cells Lee-Hwa Tai, Jiqing Zhang, Karen J. Scott, Christiano Tanese de Souza, Almohanad A. Alkayyal, Anu Abhirami Ananth, Shalini Sahi, Robert A. Adair, Ahmad Bakur Mahmoud, Subash Sad, Jo...
متن کاملPreventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination
Surgical resection is the mainstay of treatment for solid tumors, but the postoperative period is uniquely inclined to the formation of metastases, largely due to the suppression of natural killer (NK) cells. We found that preoperative influenza vaccination prevents postoperative NK-cell dysfunction, attenuating tumor dissemination in murine models and promoting the activation of NK cells in ca...
متن کاملAttacking Postoperative Metastases using Perioperative Oncolytic Viruses and Viral Vaccines
Surgical resection of solid primary malignancies is a mainstay of therapy for cancer patients. Despite being the most effective treatment for these tumors, cancer surgery has been associated with impaired metastatic clearance due to immunosuppression. In preclinical surgery models and human cancer patients, we and others have demonstrated a profound suppression of both natural killer (NK) and T...
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تاریخ انتشار 2013